The award was presented at a ceremony in Newton Park on Thursday with VWSA edging pharmaceutical company Aspen for the top spot.
Shatterprufe another well-known national brand based in NMB rounded off the top three with the third position.
Nelson Mandela Bay Municipality Executive Mayor Dr Danny Jordaan acknowledged the crucial role played by businesses in boosting the local economy.
He encouraged the business sector to keep investing in the metro in order to achieve the goals of eradicating poverty, unemployment, and inequality.
The Eastern Cape Premier, Phumulo Masualle said the Metro had R1.7 billion in the bank, and if the council decides to continue in this vein, it will stabilise and strengthen the financial position of the metro.