Regular captain Pierre Spies will only play off the bench in his return to first class rugby after more than 12 months on the sidelines.
The former Springbok flanker captained the Bulls in the Currie Cup competition in the past.
Another former captain, Victor Matfield, will travel to London as part of the coaching team and not as a player.
Matfield will not be in action over the weekend.
A number of Springboks who travelled to Europe in November will start the match, but flyhalf Handre Pollard will only be used off the bench, as a result of a foot injury from which he continues to recover.
Jan Serfontein and Francois Hougaard will start, as well as Trevor Nyakane, who missed the season-opening friendly against the Cheetahs last weekend due to a back spasm.
"We are keen for a competitive outing that will test our combinations selected for this match," Bulls coach Frans Ludeke said.
"We will be looking to give a number of substitutions some game-time, but we'll also be aware that momentum will be important during the match."
Bulls team: Jurgen Visser, Jamba Ulengo, JJ Engelbrecht, Jan Serfontein, Bjorn Basson, Jacques-Louis Potgieter, Francois Hougaard, Hanro Liebenberg, Lappies Labuschagne, Deon Stegmann, Grant Hattingh, Jacques du Plessis, Werner Kruger, Callie Visagie, Trevor Nyakane.
Replacements: Jaco Visagie, Mornè Mellett, Marcel van der Merwe, Dayan vd Westhuizen, RG Snyman, Nicolaas Janse van Rensburg, Roelof Smith, Pierre Spies, Piet van Zyl, Rudy Paige, Handrè Pollard, William Small-Smith, Duncan Matthews, Jesse Kriel.
Source: Sapa